Asymmetric Mannich Synthesis of α-Amino Esters by Anion-Binding Catalysis
نویسندگان
چکیده
We report a scalable, one-pot Mannich route to enantioenriched α-amino esters by direct reaction of α-chloroglycine ester as a practical imino ester surrogate. The reaction is promoted by a chiral aminothiourea, which is proposed to operate cooperatively by generating an iminium ion by chloride abstraction and an enolate by deprotonation, followed by highly stereoselective C-C bond formation between both reactive intermediates associated non-covalently within the catalyst framework.
منابع مشابه
Asymmetric synthesis of syn-propargylamines and unsaturated β-amino acids under Brønsted base catalysis
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